This research is about how to treat stress and depression that occur in human life, which focuses on the Islamic and science perceptions. As we know, many of us today often experience stress in our lives, whether at work, learning centrers, whlich iske universityies, or even when at home. Therefore, this study was conducted to determine what the cause of depression is, and what the effect ton human lifestyle. At the same time, this study was conducted to determine what the relationship between depressions in human life is,; does it affect the individual with a negative impact on or not.? And the main point of this study which is how this depression can be resolved by anyhow means, in the perspectives of Islamic and modern medicine. There are three main chapters in this study, which is at the beginning of the chapter on isthe introduction of depression and what are the causes of depression and what the impact occurred. In the second chapter, this study explains about how to treat the problem of depression, either in the perspective of Islamic or medical in modern science. Also in, this chapter explains the relationship between depression and the cycle of human life.